Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose.
نویسندگان
چکیده
Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on the degree of fragmentation only. This finding indicates that the nature of the actual binding must be the same for the different types of crystalline lactose.
منابع مشابه
The Effect of Crystalline and Amorphous Lactose on Mechanical Properties of Roller Compaction Ribbon and Tablets By Kim Gochioco Submitted to the graduate degree program in Pharmaceutical Chemistry and the Graduate
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ورودعنوان ژورنال:
- Pharmaceutisch weekblad. Scientific edition
دوره 7 5 شماره
صفحات -
تاریخ انتشار 1985